Catalog Number - 70000-PG5

The 70000‑PG5 Diamond Hydride Guard Column Cartridges are replacement guard cartridges designed to protect analytical HPLC columns from particulate contamination, strongly retained compounds, and sample‑matrix components that can degrade chromatographic performance and shorten column lifetime.

These cartridges are intended for use with a Cogent TYPE‑C™ guard column holder (sold separately) and are specifically matched to Diamond Hydride analytical columns to preserve chromatographic behavior.

Guard Cartridge Use Case: Preserving Analytical Separations

Guard cartridges function as a sacrificial stationary phase bed, capturing contaminants before they reach the analytical column.

Critical Requirement: To maintain chromatographic fidelity, the stationary phase in the guard cartridge must match the stationary phase of the analytical column.

The Diamond Hydride chemistry used in these cartridges ensures:

• No change in retention mechanism

• No loss of resolution

• No selectivity shifts

• No peak distortion or method drift

Using a guard cartridge with mismatched chemistry can degrade separation efficiency and compromise analytical results.

Construction & Cartridge Design

Each Diamond Hydride guard cartridge features:

• Stainless steel housing for durability and pressure stability

• Stainless steel frits for uniform flow distribution

• Diamond Hydride stationary phase, 4 µm particle size, 100 Å pore size

• Individual cartridge labeling for traceability

Each cartridge is shipped in a resealable black Delrin case to prevent drying, contamination, or handling damage prior to installation.

Analytical Column Compatibility

These guard cartridges are designed for use with:

• 3.0 mm ID analytical HPLC columns

• 4.0 mm ID analytical HPLC columns

• 4.6 mm ID analytical HPLC columns

They are intended for Cogent TYPE‑C™ Diamond Hydride analytical columns and similar HILIC workflows where retention‑mechanism consistency is essential.

Guard Column Installation Best Practices

To preserve chromatographic efficiency, guard cartridges should be installed as close to the analytical column inlet as physically possible.

Minimizing the distance between the guard holder and the analytical column reduces extra‑column (dead) volume, which can otherwise result in:

• Band broadening

• Reduced theoretical plates

• Loss of resolution

• Peak tailing or distortion

When installed immediately upstream of the analytical column and paired with matching Diamond Hydride stationary phase, the guard cartridge protects the analytical column without degrading chromatographic performance.

Purpose‑Built for Column Protection & Routine Replacement

The 70000‑PG5 5‑pack format is commonly selected for:

• Routine analytical laboratories

• High‑throughput environments

• Scheduled guard cartridge replacement programs

• HILIC and LC‑MS workflows requiring consistent method performance

Proper guard cartridge use can significantly extend analytical column lifetime, reduce downtime, and support long‑term reproducibility.

System Requirements

• Requires a Cogent TYPE‑C™ guard column holder (sold separately)

• Compatible with standard analytical HPLC systems

• No method changes required when stationary phases are properly matched